Ophthalmic compositions based on polyunsaturated omega-3 and...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 31/20 (2006.01) A61K 31/201 (2006.01) A61K 31/202 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2754568

The invention concerns topical compositions for the prevention and treatment of ocular pathologies, in particular inflammatory keratites and con- junctivites and dry eye syndrome, containing as active ingredients polyunsatu- rated fatty acids of the types omega-3 and omega-6, and specifically EPA (eicosapentaenoic acid ), DHA (docosahexaenoic acid) and GLA (.gamma.-linolenic acid), mixed with vitamin E acetate and formulated in a stable composition in hydrogel, i.e. in dispersed form in an aqueous vehicle containing one or more gelling polymers. The proposed compositions are particularly indicated for use as artificial tears.

La présente invention concerne des compositions topiques pour la prévention et le traitement de pathologies oculaires, en particulier les kératites et conjonctivites inflammatoires et le syndrome de sécheresse oculaire, contenant en tant que substances actives des acides gras polyinsaturés des types oméga-3 et oméga-6, et spécifiquement EPA (acide eicosapentaénoïque), DHA (acide docosahexaénoïque) et GLA (acide ?-linolénique), mélangés avec de l'acétate de vitamine E et formulés dans une composition stable dans de l'hydrogel, c'est-à-dire sous forme dispersée dans un véhicule aqueux contenant un ou plusieurs polymères gélifiants. Les compositions proposées sont particulièrement indiquées pour utilisation en tant que larmes artificielles.

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