Ophthalmic compositions comprising calcineurin inhibitors or...

Details Ophthalmic compositions comprising calcineurin inhibitors or... Ophthalmic compositions comprising calcineurin inhibitors or...

A - Human Necessities

61

K

A61K 38/13 (2006.01) A61K 9/107 (2006.01) A61K 47/34 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2701482

The embodiments disclosed herein relate to ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors, and more particularly to methods for treating an ocular disease and/or condition using the disclosed compositions. According to aspects illustrated herein, there is provided a pharmaceutical composition that includes a calcineurin inhibitor or an mTOR inhibitor; a first surfactant with an HLB index greater than about 10; and a second surfactant with an HLB index of greater than about 13, wherein an absolute difference between the HLB index of the first surfactant and the HLB index of the second surfactant is greater than about 3, and wherein the composition forms mixed micelles.

Cette invention concerne des compositions ophtalmiques comprenant des inhibiteurs de la calcineurine ou des inhibiteurs de mTOR, et plus particulièrement des procédés permettant de traiter une maladie et/ou une pathologie oculaire à l'aide des compositions décrites. Selon les aspects illustrés ici, une composition pharmaceutique est proposée qui comprend un inhibiteur de calcineurine ou un inhibiteur de mTOR; un premier tensioactif dont l'équilibre hydrophile-lipophile est supérieur à environ 10; et un second tensioactif dont l'équilibre hydrophile-lipophile est supérieur à environ 13, où une différence absolue entre l'équilibre hydrophile-lipophile du premier tensioactif et l'équilibre hydrophile-lipophile du second tensioactif est supérieur à environ 3, et où la composition forme un mélange de micelles.

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