C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2505086
This invention relates to potent potassium channel blocker indazole derivatives or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
L'invention concerne des dérivés indazole qui sont de puissants bloqueurs de canaux potassiques, ou une formulation de tels dérivés, pour le traitement du glaucome et d'autres états occasionnant une tension intraoculaire élevée dans l'oeil d'un patient. L'invention concerne également l'utilisation de tels composés en vue d'obtenir un effet neuro-protecteur pour l'oeil de sujets mammifères, et notamment, humains.
Chen Meng-Hsin
Doherty James B.
Liu Luping
Natarajan Swaminathan R.
Tynebor Robert M.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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