A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/08 (2006.01)
Patent
CA 2278802
There are disclosed ophthalmic compositions having high water-binding properties which are useful as: moisturizing and lubricating (i.e. artificial tear) solutions, dry eye therapies, contact lens wetting and lubricating solutions, and as delivery vehicles for ophthalmic drugs. The subject compositions include glycerin in combination with propylene glycol. The subject compositions may further include cellulose derivatives, e.g. hydroxypropyl methyl cellulose, along with preservatives, e.g. benzylalkonium chloride, PHMB, sorbic acid, etc.. Preferred compositions have at least 11 % bound water, a pH from about 7.1 to 7.5, and an osmolality between about 280 to about 320 mOsm/Kg.
L'invention concerne des compositions ophtalmiques dotées de propriétés hydrophiles élevées, qui sont utiles comme: solutions hydratantes et lubrifiantes (c.-à-d. larmes artificielles), traitement d'yeux secs, solutions d'humidification et de lubrification de verres de contact, et véhicules d'administration de médicaments ophtalmiques. Les compositions en question renferment de la glycérine en combinaison avec du propylène glycol. Elles peuvent en outre renfermer des dérivés de cellulose, p. ex. de l'hydroxypropylméthylcellulose, ainsi que des agents de conservation, p. ex. du chlorure de benzalconium, du PHMB, de l'acide sorbique, etc. Des compositions préférées renferment au moins 11 % d'eau liée, ont un pH de 7,1 à 7,5 environ, et une osmolalité comprise entre 280 environ et 320 mOsm/kg environ.
Denick John
Hu Zhenze
Bausch & Lomb Incorporated
Osler Hoskin & Harcourt Llp
LandOfFree
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