Ophthalmic compositions including oil-in-water emulsions,...

A - Human Necessities – 61 – K

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A61K 9/107 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2474349

Ophthalmic compositions comprising an oil-in water emulsion, preferably a self- emulsifying oil-in water emulsion, including an oily component, an aqueous component and a surfactant component. The surfactant component may include three or more surfactants, for example, a polyoxyalkalene alkylene ether, a polyalkylene oxide ether of alkyl alcohol and a polyalkylene oxide ether of alkylphenol. The present compositions may include therapeutic components. Methods of making such compositionbs and using such compositions, for example, to treat eyes, to treat contact lenses and to provide desired therapeutic effects are provided.

L'invention concerne des compositions ophtalmiques qui contiennent une émulsion de type aqueux, de préférence une émulsion de type aqueux auto-émulsifiante émulgente, qui renferme un composant huileux, un composant aqueux et un composant tensio-actif. Le composant tensioactif peut contenir trois tensioactifs ou plus, par exemple, un éther polyoxyalcalène d'alkylène, un étheroxyde de polyalkylène d'alcool alkylique et un étheroxyde de polyalkylène d'alkylphénole. Ces compositions peuvent également comprendre des composants thérapeutiques. L'invention concerne par ailleurs des procédés de préparation et d'utilisation de ces compositions, par exemple, pour traiter les yeux, les lentilles de contact et obtenir les effets thérapeutiques recherchés.

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