Ophthalmic compositions with an amphoteric surfactant and...

A - Human Necessities – 61 – K

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A61K 8/19 (2006.01) A61K 8/20 (2006.01) A61K 8/41 (2006.01) A61K 8/43 (2006.01) A61K 8/44 (2006.01) A61K 8/73 (2006.01) A61K 8/81 (2006.01) A61K 8/90 (2006.01)

Patent

CA 2713308

Ophthalmic compositions that comprise 0.1 ppm to 10 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt.% to 0.15 wt.% of hyaluronic acid; and 0.01 wt.% to 1.0 wt.% of an amphoteric surfactant of general formula I wherein R1 is R or -(CH2)n-NHC(O)R, wherein R is a C8-C16alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R4 is a C2-C8alkylene optionally substituted with hydroxyl. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.

L'invention concerne des compositions ophtalmiques qui comprennent de 0,1 ppm à 10 ppm d'un composant antimicrobien cationique choisi dans le groupe comprenant les biguanides, les biguanides polymères, les composés d'ammonium quaternaire et l'un quelconque de leurs mélanges; de 0,005 % en poids à 0,15 % en poids d'acide hyaluronique; et de 0,01 % en poids à 1,0 % en poids d'un agent tensioactif amphotère de formule générale I dans laquelle R1 est R ou -(CH2)n-NHC(O)R, où R est un groupe alkyle en C8 à C16 éventuellement substitué par un groupe hydroxyle et n vaut 2, 3 ou 4; R2 et R3 sont chacun indépendamment choisis parmi les groupes méthyle, éthyle, propyle ou isopropyle; et R4 est un groupe alkylène C2 à C8 éventuellement substitué par un groupe hydroxyle. L'invention concerne également l'utilisation des compositions ophtalmiques pour nettoyer et désinfecter des lentilles de contact, et en particulier des lentilles de contact souples en hydrogel de silicone.

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