Ophthalmic device, and method of use thereof, for increasing...

Details Ophthalmic device, and method of use thereof, for increasing... Ophthalmic device, and method of use thereof, for increasing...

A - Human Necessities

61

L

A61L 31/16 (2006.01) A61F 9/00 (2006.01) A61P 27/04 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2723144

The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device comprises an ophthalmic lens and a sacrificial mechanism disposed on the ophthalmic lens, wherein the sacrificial mechanism comprises a plurality of surface bound receptors, such as PRG4, hyaluronic acid, and DNA aptamers, that reversibly bound to a lubricating composition comprising a gel forming agent, a surfactant, or a combination thereof, effectively inhibiting or preventing protein and lipid adsorption on the surface of the lens, and mitigate shear stress and reduce the friction between the lens and the ocular surface of the individual in need.

La présente invention concerne un dispositif ophtalmique ainsi qu'un procédé d'utilisation correspondant pour un individu portant une lentille ophtalmique afin d'augmenter la lubrification limite de la surface oculaire. Le dispositif décrit dans l'invention comprend une lentille ophtalmique et un mécanisme sacrificiel disposé sur la lentille ophtalmique. Le mécanisme sacrificiel comprend plusieurs récepteurs fixés en surface, tels que le PRG4, l'acide hyaluronique et les aptamères d'ADN, qui se fixent de manière réversible à une composition lubrifiante comprenant un agent gélifiant, un tensioactif ou une combinaison des deux, bloquant ou empêchant efficacement l'adsorption des protéines et des lipides sur la surface de la lentille, et qui atténuent la contrainte de cisaillement et réduisent le frottement entre la lentille et la surface oculaire de l'utilisateur.

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