Ophthalmic drug delivery system using polymer micelle

Details Ophthalmic drug delivery system using polymer micelle Ophthalmic drug delivery system using polymer micelle

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 31/409 (2006.01) A61K 47/34 (2006.01) A61K 47/42 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2520525

The current situation is such that it is difficult for drugs to reach posterior tissues of eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that effective delivery of drugs to posterior tissues of eyeball, such as choroid and retina, especially those wherein vascularization has occurred can be accomplished by systemic administration, especially intravenous administration of polymer micells having a drug incorporated therein. Further, it has been found that when a photosensitive substance is used as a drug and PDT is carried out, choroidal neo-vessels can be effectively choked so as to be useful for the treatment of age-related macular degeneration.

Les médicaments actuels atteignent difficilement les tissus postérieurs du globe oculaire, tels que la choroïde et la rétine, ce qui rend difficile le traitement d'affections dans ces zones. Il est donc essentiel de rechercher une méthode de libération de médicament efficace. On a découvert que la libération efficace de médicaments dans les tissus postérieurs du globe oculaire, tels que la choroïde et la rétine, notamment ceux dans lesquels une vascularisation est présente, peut s'effectuer par administration systémique, notamment par administration intraveineuse de cellules polymériques dans lesquelles un médicament est incorporé. De plus, on a découvert que lorsqu'une substance photosensible est utilisée en tant que médicament et qu'une thérapie photodynamique est menée à bien, les néovaisseaux choroïdiens peuvent être engorgés efficacement, ce qui permet le traitement de la dégénérescence maculaire liée à l'âge.

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