Ophthalmic solutions and methods for improving the comfort...

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A - Human Necessities

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K

167/265, 167/279

A61K 9/12 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01) A61K 9/113 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1293448

Ophthalmic solutions and methods for improving the comfort and safety of contact lenses Abstract An ophthalmic solution for improving the exchange of fluid in the area outside a hydrogel contact lens with the fluid in the area underneath the hydrogel contact lens comprising: (a) a hydrogel contact lens flattening agent in an amount from 0.0005 % by weight to an amount equivalent to 330 millios- moles/kg, optionally (b) an ophthalmically acceptable ionic salt in an amount sufficient to render said solution substantially isotonic, and (c) an ophthalmically acceptable viscosity enhancing agent suffi- cient to cause the composition to have a Brookfield relative viscosity of 3 to 50 cps. The invention also includes a method for improving the exchange of fluid in the area outside a hydrogel contact lens with the fluid in the area underneath the hydrogel contact lens in a human eye comprising adding to said eye an effective amount of such ophthalmic solutions.

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