Ophthalmic solutions containing tetrazole derivatives

A - Human Necessities – 61 – K

Patent

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A61K 31/41 (2006.01) A61K 9/00 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/4745 (2006.01) A61K 33/22 (2006.01) A61K 45/06 (2006.01) A61K 47/18 (2006.01) A61P 27/02 (2006.01) C07D 257/04 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2478685

An additive which enhances the antiseptic effect of a cationic antiseptic in eye drops containing a compound having a chemical structure represented by the following general formula (I). Incorporating a basic amine compound into eye drops containing the compound having a chemical structure represented by the general formula (I) and a cationic antiseptic remarkably enhances the antiseptic effect on the eye drops. In the general formula (I), R1 is any of the following structural formulae (Ia), (Ib), (Ic), (Id), (Ie), and (If).

L'invention concerne un additif permettant d'améliorer l'effet antiseptique d'un antiseptique cationique dans des gouttes ophtalmologiques. Ledit additif contient un composé comprenant une structure chimique représentée par la formule (I). L'incorporation d'un composé amine basique dans des gouttes ophtalmologiques contenant un composé dont la structure chimique est représentée par la formule (I) et d'un antiseptique cationique permet d'améliorer, de manière remarquable, l'effet antiseptique de ces gouttes ophtalmologiques. Dans la formule (I), R?1 ¿est représenté par l'une quelconque des formules suivantes: (Ia), (Ib), (Ic), (Id), (Ie) et (If).

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