A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 47/36 (2006.01)
Patent
CA 2248881
The present invention relates to an ophthalmological composition intended for contacting with the lacrimal fluid wherein said composition is intended to be administered as a non-gelled liquid form and is intended to gel in situ, this composition containing at least one polysaccharide in aqueous solution, of the type which undergoes liquid-gel phase transition gelling in situ under the effect of an increase in the ionic strength of said lacrimal fluid and a pharmaceutically active substance characterised in that said pharmaceutically active substance is pilocarpine or a pharmaceutically acceptable salt thereof, wherein said composition comprises a first component which is an acid aqueous solution of pilocarpine and a second component which is a neutral or alkaline aqueous solution of a polysaccharide of the type which undergoes liquid-gel phase transition under the effect of an increase in the ionic strength, said components being mixed extemporaneously at the time of first use.
La présente invention se rapporte à une composition ophtalmologique destinée à être mise en contact avec le fluide lacrimal, à être administrée sous une forme liquide non gélifiée et à se gélifier in situ. Cette composition renferme au moins un polysaccharide dans une solution aqueuse et subit une transition de phase liquide-gel se gélifiant in situ sous l'effet d'une augmentation de la force ionique du fluide lacrimal. L'invention concerne également une substance pharmaceutiquement active telle que la pilocarpine ou un sel pharmaceutiquement acceptable de celle-ci. La composition comprend un premier composant qui est une solution aqueuse acide de policarpine et d'un second composant qui est une solution aqueuse neutre ou alcaline d'un polysaccharide qui subit la transition de phase liquide/gel sous l'effet d'une augmentation de la force ionique, ces composants étant mélangés extemporanément au moment de leur première utilisation.
Chastaing Gilles
Rozier Annouk
Laboratoires Merck Sharp & Dohme-Chibret Snc
Swabey Ogilvy Renault
LandOfFree
Ophthalmological composition of the type which undergoes... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ophthalmological composition of the type which undergoes..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ophthalmological composition of the type which undergoes... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2088418