Opiate intermediates and methods of synthesis

Details Opiate intermediates and methods of synthesis Opiate intermediates and methods of synthesis

C - Chemistry, Metallurgy

07

D

C07D 217/20 (2006.01) C07C 233/01 (2006.01) C07D 221/28 (2006.01)

Patent

CA 2585698

Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided. The intermediates are morphinane derivatives of formula (10) wherein X is a F or Cl and R is selected from the group consisting of an H, alkyl, aryl, acyl, formyl, COR~, CONHR~, COOR, Bn(benzyl), alkyl(methyl), and sulfonamide SO2CH2COPh.

L'invention concerne de nouvelle compositions d'intermédiaires opiacés, ainsi que des procédés de synthèse consistant à modifier le modèle de substitution sur le cycle aromatique de l'intermédiaire pré-Grewe.

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