Opioid agonist/antagonist combinations

Details Opioid agonist/antagonist combinations Opioid agonist/antagonist combinations

A - Human Necessities

61

K

A61K 31/485 (2006.01)

Patent

CA 2314893

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative "aversive" experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

L'invention porte partiellement de doses orales comportant une combinaison d'une quantité à effet analgésique d'un agoniste d'opioïde et d'un antagoniste d'opioïde oralement actif. Le rapport entre les quantités d'antagoniste et d'agoniste est tel que le produit combiné à un effet analgésique lorsqu'administré oralement, mais un effet "d'aversion" chez un sujet physiquement dépendant. La quantité d'antagoniste d'opioïde du produit combiné a de préférence un effet légèrement négatif et "d'aversion" chez les toxicomanes en dépendance physique (syndrome d'abstinence précipitée).

Affiliated with

Also associated with

Rating

Opioid agonist/antagonist combinations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Opioid agonist/antagonist combinations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Opioid agonist/antagonist combinations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1977263