Opioid agonist formulations with releasable and sequestered...

A - Human Necessities – 61 – K

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Details

A61K 31/485 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61P 25/04 (2006.01) A61P 25/36 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2457361

Disclosed are oral dosage forms, comprising (i) a therapeutically effective amount of an opioid agonist; (ii) an opioid antagonist in releasable form; and (iii) a sequestered opioid antagonist which is not released when the dosage form is administered intact, and methods thereof.

L'invention concerne des formes galéniques orales comprenant (i) une quantité efficace sur le plan thérapeutique d'un agoniste opioïde; (ii) un antagoniste opioïde dans une forme à libération; et (iii) un antagoniste opioïde séquestré qui n'est pas libéré quand la forme galénique est administrée de manière intacte, ainsi que des procédés associés.

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