Opioid peptides

Details Opioid peptides Opioid peptides

C - Chemistry, Metallurgy

07

K

C07K 7/00 (2006.01) C07K 5/00 (2006.01) C07K 5/02 (2006.01) C07K 5/087 (2006.01) C07K 5/107 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2126697

2126697 9411018 PCTABS00032 Opioid peptides including those of formula (I), in which A1 is the identifying group of an amino acid selected from 3,4-dihydroxyphenylalanine, 3,4-dimethoxyphenylalanine, azatyrosine, and 2,6-dimethyltyrosine; A2 is the identifying group of an amino acid selected from D-Ala and D-Arg; A3 is H, or the identifying group of an amino acid selected from 3,4-dihydroxyphenylalanine and 3,4-dimethoxyphenylalanine, A4 is H, cyclohexylmethyl, the identifying group of an amino acid selected from 3,4-dihydroxyphenylalanine, 3,4-dimethoxyphenylalanine, Phe, and substituted Phe with its benzene ring substituted by halogen, NO2, OH, or CH3; A5 is the identifying group of a D- or L-amino acid selected from Leu, Nle, Lys, Met and Met(O), or is deleted together with R4-CH attached thereto; each R1 and R2 is -H, -C(NH2) = NH, or C1-12 alkyl; R3 is -(a) or (b); R4 is (c); (d), or (e); and R5 is -(CH2)n+1OH, (f), or (g); wherein m is 0-6, n is 0-6, and X is H, C1-12 alkyl, C6-12 aryl, C7-18 aralkyl, C7-18 alkaryl, C7-18 alkaryl, C6-17 pyridylalkyl, or C6-17 alkylpyridyl; provided that when one of R1 and R2 is -C(NH2) = NH, the other must be H; or a pharmaceutically acceptable salt thereof.

Affiliated with

Also associated with

Rating

Opioid peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Opioid peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Opioid peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1895538