Opioid receptor: compositions and methods

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2175476

The invention relates generally to compositions of and methods for obtaining epsilon opioid receptor polypeptides. The invention relates as well to polynucleotides encoding epsilon opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant opioid receptor polypeptides. The invention includes as well methods for using the isolated, recombinant receptor polypeptide in assays designed to select and improve substances capable of interacting with epsilon opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.

La présente invention concerne généralement des compositions et des procédés d'obtention de polypeptides récepteurs d'opioïdes epsilon. L'invention concerne également des polynucléotides codant les polypeptides récepteurs des opioïdes epsilon, les vecteurs recombinés véhiculant ces séquences, les cellules hôtes recombinées contenant soit lesdites séquences soit lesdits vecteurs ainsi que des polypeptides recombinés récepteurs d'opioïdes. L'invention concerne également des procédés d'utilisation d'un tel polypeptide récepteur isolé recombiné, dans des dosages destinés à sélectionner et améliorer les substances capables d'entrer en interaction avec les polypeptides récepteurs d'opioïdes epsilon afin de les utiliser pour le diagnostic, la conception de médicaments et des applications thérapeutiques.

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