Opsin stabilizing compounds and methods of use

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/662 (2006.01) A61K 31/12 (2006.01) A61K 31/275 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/506 (2006.01) A61P 27/02 (2006.01) C07K 1/00 (2006.01) C07K 14/705 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2657015

The present invention provides compositions and methods useful in the treatment and/or prevention of ophthalmic conditions and diseases, such as retinitis pigmentosa, that are dependent upon or related to misfolded opsin proteins in vivo. In addition, screening assays for agents useful in such treatment methods are described.

La présente invention se rapporte à des compositions et à des méthodes destinées à traiter et/ou à prévenir des troubles et des maladies ophtalmologiques, comme la rétinite pigmentaire, qui sont causés par des protéines opsines mal repliées in vivo ou associés à ces dernières. L'invention concerne également des procédés de criblage permettant d'identifier des agents utiles pour de telles méthodes de traitement.

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