C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) C07K 1/00 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C12N 5/12 (2006.01) C12P 21/04 (2006.01)
Patent
CA 2469715
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.
La présente invention concerne des anticorps monoclonaux qui se fixent à l'acide lipotéichoïque de bactéries Gram-positif. Lesdits anticorps se fixent également à ces bactéries et favorisent la phagocytose et la mort desdites bactéries in vitro. L'invention concerne également des anticorps présentant des séquences humaines (anticorps chimériques, humanisés et humains). L'invention concerne en outre des régions variables de trois anticorps et porte sur l'homologie frappante qu'il existe entre eux.
Fischer Gerald Walter
Lees Andrew
Mond James J.
Schuman Richard F.
Stinson Jeffrey R.
Biosynexus Incorporated
Kirby Eades Gale Baker
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