Opthalmic preparation for use as artificial tear

Details Opthalmic preparation for use as artificial tear Opthalmic preparation for use as artificial tear

A - Human Necessities

61

K

A61K 31/728 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61P 27/04 (2006.01) A61K 31/725 (1995.01)

Patent

CA 2154533

Ophthalmic preparation for use as artificial tear containing hyaluronate as a viscosity thickener, preferably in the form of sodic salt and having a molecular weight of 500,000 to 4,000,000 daltons, at a concentration of 0.05 to 2% by weight, as well as the following minimum quantities of ionic species: 40 mmol/l sodium ion, 12 mmol/1 potassium ion, 0.4 mmol/l calcium ion, 0.4 mmol/l magnesium ion, 50 mmol/1 chloride ion, 7 mmol/l phosphate ion and, preferably, 0.7 mmol/1 citrate ion. The formulation, which as an osmolarity of 140 to 280 mOsm/1, is useful for the treatment of keratoconjunctivitis sicca and may be administered whenever the use of artifical tears is advisable, e.g. for the treatment of eye irritations caused by environmental conditions or contact lenses.

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