Opthalmic solution with tetracycline for topical treatment...

A - Human Necessities – 61 – K

Patent

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A61K 31/65 (2006.01) A61K 33/14 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2339792

Ophthalmic compositions and methods of using the same to simultaneously treat eye surface inflammation and dry eye are disclosed. The ophthalmic preparation contains a tetracycline compound in aqueous solution,. The preparation preferably further includes a balance of electrolytes sufficient to maintain or restore essentially normal levels of conjunctival mucus-containing goblet cells and corneal glycogen. These electrolytes can include potassium, chloride, bicarbonate, sodium, calcium, magnesium and phosphate.

L'invention porte sur des compositions ophtalmiques et sur leurs procédés d'utilisation pour traiter simultanément une inflammation à la surface de l'oeil et l'oeil sec. La préparation ophtalmique contient un composé de tétracycline en solution aqueuse. La composition comprend de préférence un reste d'électrolytes suffisant pour conserver et rétablir essentiellement les taux normaux des cellules caliciformes conjonctivales renfermant le mucus et le glycogène cornéen. Ces électrolytes peuvent comprendre le potassium, le chlore, le bicarbonate, le sodium, le calcium, le magnésium et le phosphate.

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