Optical determination of glucose utilizing boronic acid adducts

Details Optical determination of glucose utilizing boronic acid adducts Optical determination of glucose utilizing boronic acid adducts

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 49/00 (2006.01) C07D 401/10 (2006.01) G01N 33/52 (2006.01) G01N 33/66 (2006.01)

Patent

CA 2436590

The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

L'invention concerne un procédé optique amélioré et un dispositif de détection optique destinés à déterminer les niveaux de molécules organiques <i>in vitro</i> et/ou <i>in vivo</i> substituées par polyhydroxyle dans un milieu aqueux. Plus particulièrement, un dispositif sensoriel est mis en oeuvre chez un mammifère afin de déterminer les niveaux de sucre, et un colorant est combiné avec un composé bisonium substitué par un acide borique aromatique hétérocyclique contenant de l'azote conjugué en présence d'un sucre, tel que du fructose ou du glucose. Les composés substitués par un acide borique contenant de l'azote conjugué aromatique sont, de préférence, des viologènes. Le procédé de l'invention est utilisé afin de déterminer les niveaux de sucre chez un être humain.

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