Optical determination of ph and glucose

Details Optical determination of ph and glucose Optical determination of ph and glucose

G - Physics

01

N

G01N 33/66 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2674513

Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.

L'invention concerne un capteur optique qui est capable de mesurer simultanément deux analytes avec un système d'indicateur unique. Selon des modes préférés de réalisation, le capteur comprend un colorant fluorescent ayant des formes acides et basiques qui facilitent une détection de pH ratiométrique, de sorte que le colorant est en outre associé à un fragment de liaison au glucose et configuré pour générer un signal qui varie en intensité avec la concentration de glucose.

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