G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 21/64 (2006.01) G01N 33/554 (2006.01) G02B 21/16 (2006.01)
Patent
CA 2093532
TITLE Optical Fibre Epifluorescense Biosensor ABSTRACT A distal-end sensing optical fiber objective extension for use in quantitative fluorescence assay studies with a fluorescence microscope comprises optical fibre means. Also included are: a length of optical fibre having proximal and distal ends, adapted to transmit fluorescence emitted from an excited sample, from the distal end to the proximal end. A proximal end alignment stage is operable to selectively position the proximal end in a plane oriented in substantially focused relation with an adjacent objective fluorescence- microscope lens. A distal end/stage alignment stage is operable to selectively position the distal end relative to a sample stage in substantially focused relation to a sample borne on that sample stage. In this arrangement, fluorescence emitted from the sample is captured from within a relatively deep, distal end depth-of-field. The captured fluorescence is then transmitted to the proximal end, from which it is then re-transmitted from the above-mentioned plane located within the objectives relatively shallower depth-of-field. This arrangement admits sample fluorescence sensed from the relatively deeper depth-of-field, into focused relation with the objective lens to thereby enable improved quantitative fluorescence assay sensitivity.
Jiang Lian W.
Margaritis Argyrios
Petersen Nils Overgaard
Jiang Lian W.
Kerr James W.
Margaritis Argyrios
Petersen Nils Overgaard
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