Optical isomers

Details Optical isomers Optical isomers

C - Chemistry, Metallurgy

07

D

167/231, 260/272

C07D 497/20 (2006.01) A61K 31/445 (2006.01)

Patent

CA 1336601

The (+)-?-, (-)-?-, (+)-?- and (-)-?- forms of 2-methylspiro(1,3-oxathiolan-5,3')quinuclidine are prepared by optical resolution of each of the (?)-?- and (?)-?-isomers. These compounds find application in treating diseases of the central nervous system in mammals, especially diseases due to a deficiency in the central cholinergic system. Biological tests indicate that the (-)-?-form, as well as the (?)-?-isomer, shows particular promise for treating senile dementia of Alzheimer's type.

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