Optical isomers of an imidazole derivative

Details Optical isomers of an imidazole derivative Optical isomers of an imidazole derivative

C - Chemistry, Metallurgy

07

D

167/237, 260/314

C07D 233/58 (2006.01) A61K 31/415 (2006.01) C07D 233/54 (2006.01)

Patent

CA 1337659

Optically active d- and l-isomers of 4-[1-(2,3- dimethylphenyl)ethyl]-1H-imidazole (known as medetomidine) or their non-toxic, pharmaceutically-acceptable, acid- addition salts, are provided herein. Pharmaceutical compositions contains the d-enantiomers of medetomidine, and pharmaceutical compositions containing the separated d- or l-enantiomers of medetomidine are also provided herein. Methods for the separation of the d- and l-isomers are also taught. The separated enantiomers are useful in a method of sedation/analgesia, or the treatment of anxiety or hypertension, or in therapy or as a selective .alpha.2-receptor agonist.

572086

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