Optical isomers of dihydro-2,3-benzodiazepines and their...

C - Chemistry – Metallurgy – 07 – C

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C07C 251/86 (2006.01) A61K 31/551 (2006.01) A61P 25/00 (2006.01) C07C 309/66 (2006.01) C07D 243/02 (2006.01) C07D 311/58 (2006.01) C07D 317/58 (2006.01) C07D 491/04 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2633804

The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and the preparation thereof and the used intermediates as well. These compounds have anti-convulsiveA muscle relaxant and neuroprotective effect due their non-competitive AMPA antagonistic properties. Image

La présente invention concerne des composés de dihydro-2,3-benzodiazépine de pureté énantiomérique élevée selon la formule générale (I), qui contiennent un centre asymétrique à la position 4 du composé de dihydro-2,3-benzodiazépine, et leur préparation ainsi que les intermédiaires utilisés. Ces composés ont un effet myorelaxant anticonvulsif neuroprotecteur en raison de leurs propriétés antagonistes d'AMPA non compétitives.

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