Optical method for the detection of alzheimer's disease

Details Optical method for the detection of alzheimer's disease Optical method for the detection of alzheimer's disease

A - Human Necessities

61

B

A61B 6/00 (2006.01) A61B 5/00 (2006.01) A61B 6/12 (2006.01) A61F 9/00 (2006.01) A61K 49/00 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2735869

The present subject matter relates to a non-invasive optical imaging method for monitoring ear-ly pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events pro-vides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addi-tion, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. A.beta.-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present inven-tion is based on studies focusing on the eyes as an alter-native to brain-derived tissue that can be imaged direct-ly, repetitively and non-invasively.

La présente invention concerne un procédé d'imagerie optique non invasif pour surveiller des événements pathologiques précoces spécifiques de la maladie d'Alzheimer (AD), tels que le développement, la quantité et l'emplacement de plaques amyloïdes. La capacité à surveiller de tels événements fournit une base pour établir, entre autres, un diagnostic de la maladie d'Alzheimer, un pronostic et une évaluation de thérapies potentielles. De plus, la présente invention présente de nouveaux procédés pour traiter la maladie d'Alzheimer et des affections rétiniennes associées à la maladie d'Alzheimer. La détection de plaque Aß dans des cerveaux vivants est extrêmement limitée, en particulier à une résolution élevée; par conséquent, la présente invention est fondée sur des études qui se concentrent sur les yeux, en tant qu'alternatives à des tissus dérivés du cerveau, qui peuvent être imagés directement, de manière répétitive et non invasive.

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