Optical resolution method of amlodipine

Details Optical resolution method of amlodipine Optical resolution method of amlodipine

C - Chemistry, Metallurgy

07

D

C07D 211/90 (2006.01)

Patent

CA 2589099

The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O'-dibenzoyl tartaric acid as chiral reagent., More particularly, the present invention relates to a method comprising (a) obtaining (R)- or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O'-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)- or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.

L'invention concerne un procédé qui permet la résolution optique des amlodipines au moyen d'un solvant isopropanol et d'un acide tartrique de O,O'-dibenzoyle optiquement actif comme réactif chiral. L'invention se rapporte, en particulier, à un procédé qui consiste: (a) à obtenir un sel tartrate de dibenzoyle de (R) ou (S) amlodipine ou un solvate de ce dernier en faisant réagir des (R, S) amlodipines avec un acide tartrique de O,O'-dibenzoyle optiquement actif dans un solvant isopropanol, et (b) à traiter le sel de (R) ou (S) amlodipine avec une base, afin d'obtenir une amlodipine optiquement active.

Affiliated with

Also associated with

Rating

Optical resolution method of amlodipine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optical resolution method of amlodipine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optical resolution method of amlodipine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1682708