Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid

Details Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid

C - Chemistry, Metallurgy

07

C

C07C 233/05 (2006.01) A61K 31/197 (2006.01) A61P 25/08 (2006.01) C07C 215/30 (2006.01) C07C 227/16 (2006.01) C07C 229/08 (2006.01) C07C 231/20 (2006.01)

Patent

CA 2604624

The invention relates to pure (R)-CMH and to the optical resolution of CMH- racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)-CMH and to the process for isolatin (S)-CMH from the mother liquor.

L'invention concerne la purification de (R)-CMH et la résolution optique du CMH- racémate, un intermédiaire clé dans la synthèse de (S)-prégabaline. L'invention concerne également le procédé de purification optique de (R)-CMH et le procédé permettant d'isoler (S)-CMH de la solution mère.

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