Optical resolution of aminoisobutyric acid

Details Optical resolution of aminoisobutyric acid Optical resolution of aminoisobutyric acid

C - Chemistry, Metallurgy

07

C

C07C 229/08 (2006.01) C07C 227/20 (2006.01) C07C 227/34 (2006.01) C07C 269/08 (2006.01) C07C 271/22 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2310425

A process for resolving amino protected racemic 3-amino-2- methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recrystallizing the diastereomeric salts from ethyl acetate to separate the diastereomeric salts into crystal fractions; and (3) releasing the resolved acid from the diastereomeric salt by treating the diastereomeric salt with a basic solution is disclosed. A process for the preparation of the cryptophycin molecules is also disclosed.

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