G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 19/04 (2006.01) C12Q 1/68 (2006.01) G01N 21/75 (2006.01) G01N 33/543 (2006.01) G01N 33/552 (2006.01) G21K 1/00 (2006.01) H05H 3/04 (2006.01)
Patent
CA 2223576
Tightly focused beams of laser light are used as "optical tweezers" to trap and manipulate polarizable objects such as microspheres of glass or latex with diameters on the order of 4.5 µm. When analytes are allowed to adhere to the microspheres, small quantities of these analytes can be manipulated, thus allowing their detection and quantitation even when amounts and concentrations of the analytes are extremely small. Illustrative examples include measuring the strength needed to break antibody-antigen bonds and the detection of DNA sequences.
Des faisceaux de lumière laser parfaitement focalisés sont utilisés comme "pinces optiques" pour piéger et manipuler des objets polarisables tels que des microsphères de verre ou de latex dont les diamètres sont de l'ordre de 4,5 µm. Lorsqu'on fait adhérer les analytes aux microsphères, il est possible d'en manipuler de petites quantités, ce qui permet de les détecter et de les quantifier même lorsque les quantités et les concentrations de ces analytes sont extrêmement faibles. Des exemples servant à illustrer cette invention consistent à mesurer la force nécessaire pour séparer les liaisons anticorps-antigènes et réaliser la détection des séquences d'ADN.
Helmerson Kristian Peter
Kishore Rani Bakhru
Weetall Howard Hayyam
Macrae & Co.
United States Government As Represented By The Secretary Of Commerce Na Tional Institute
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