Optically active...

Details Optically active... Optically active...

C - Chemistry, Metallurgy

07

D

C07D 207/26 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2329576

The present invention relates to optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinones and pharmaceutically acceptable salts thereof, to processes for their preparation, to isotopically-labeled analogs thereof, to pharmaceutical compositions comprising them and to their medicinal use as selective antagonists of the 5-HT 1D receptor. The compounds of the invention are useful in treating depression, obsessive- compulsive disorder (OCD) and diseases, disorders or conditions for which a 5-HT,1D receptor selective antagonist is therapeutically indicated.

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