Optically active aminoketone derivative and method for...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/06 (2006.01) A61K 31/42 (2006.01) C07D 261/08 (2006.01)

Patent

CA 2061785

- 27 - ABSTRACT OF THE DISCLOSURE 3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl]- isoxazole is reacted with optically active 10-camphor- sulfonic acid in a solvent such as an alkyl acetate ester to form a diastereomer salt which is slightly soluble in the solvent, and the salt is then isolated. Afterward, the diastereomer salt is demineralized, isolated as a hydro- chloride, and then purified to obtain an optically active aminoketone derivative. According to this method, the optically active aminoketone derivative can be obtained from a racemic aminoketone derivative in a high purity and in a high yield, and in consequence, an excellent centrally acting muscle relaxant can be provided.

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