Optically active benzyl alcohol compound and the use thereof

Details Optically active benzyl alcohol compound and the use thereof Optically active benzyl alcohol compound and the use thereof

C - Chemistry, Metallurgy

07

C

167/274, 260/612

C07C 215/60 (2006.01) A61K 31/315 (2006.01)

Patent

CA 2026216

A levo-rotatory enantiomer of benzyl alcohol compound represented by the following formula (I): (see figure 1) wherein ~ C represents an asymmetric carbon atom; a pharmacologically acceptable salt of the compound; and a method for preparing the enantiomer is disclosed. Also disclosed are methods for ralaxing uterine smooth muscle and bladder smooth muscle comprising administering the levvo-rotatory enantiomer. Further disclosed is a pharmaceutical composition for the treatment of premature labor or incontinence of urine comprising an effective amount of the levo-rotatory enantiomer together with a pharmaceutically acceptable carrier or coating. Lastly disclosed are methods for the treatment of premature labor or incontinence of urine comprising the steps of determining that a mammal has one of these illnesses and administering the levo-rotatory enantiomer to the mammal.

Divulgation concernant un énantiomère lévogyre de l'alcool benzylique - représenté par la formule (I) (voir figure 1) où ~ C représente un atome de carbone asymétrique -, un sel de ce composé, de qualité pharmacologique, et une méthode pour préparer l'énantiomère. La divulgation concerne également des méthodes pour relâcher le muscle lisse utérin et le muscle lisse de la vessie, consistant à administrer l'énantiomère lévogyre; elle concerne de plus une composition pharmaceutique pour le traitement de l'accouchement prématuré ou de l'incontinence urinaire, comprenant une quantité efficace de l'énantiomère lévogyre associé à un véhicule ou à un enrobage de qualité pharmaceutique. Enfin, on divulgue des méthodes pour le traitement de l'accouchement prématuré ou de l'incontinence urinaire, comprenant les étapes qui consistent à déterminer qu'un mammifère souffre de l'une de ces affections et à lui administrer l'énantiomère lévogyre.

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