Optically active imidazolidinone derivative and process for...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2172162

The invention relates to a stereoisomer 3-(R)-imidazolidinonyl piperidine of the following structure: Image wherein R and R1, independently, denote hydrogen atoms, halogen atoms, lower alkyl groups which may be substituted by halogen atoms, lower alkoxy groups, lower alkylthio groups; lower alkoxycarbonyl groups, vitro groups, amino groups or cyano groups, and n denotes 1 to 4, or an acid addition salt thereof. These optically active imidazolidinone derivatives have cholinergic activity (a muscarine M1 activity) and are useful for treating senile dementia. The invention also relates to pharmacologically acceptable acid-addition salts of these derivatives, and processes for producing them.

Sont décrits un dérivé d'imidazolidinone optiquement actif représenté par la formule générale (1), présentant une activité cholinergique (une activité muscarine M1) et étant utile pour traiter la démence sénile, son sel d'addition d'acide pharmacologiquement acceptable, ainsi qu'un procédé pour sa production. Dans ladite formule, R et R<1> peuvent être identiques ou différents et chacun représente hydrogène, halogène, alkyle inférieur éventuellement halogéné, alcoxy inférieur, alkylthio inférieur, alcoxy carbonyle inférieur, nitro, amino ou cyano; et n vaut de 1 à 4.

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