Optically active isomers of ketotifen and therapeutically...

Details Optically active isomers of ketotifen and therapeutically... Optically active isomers of ketotifen and therapeutically...

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/4535 (2006.01)

Patent

CA 2383222

Racemic norketotifen, racemic 10-hydroxy-ketotifen, racemic 10-hydroxy-nor- ketotifen and optically active isomers of ketotifen, norketotifen, 10-hydroxy-ketotifen and 10-hydroxy-norketotifen were found to have antiallergic and anti-inflammatory effects while being devoid of the severe dose-limiting sedative side effects of ketotifen.

L'invention concerne le norkétotifène racémique, le 10-hydroxy-kétotifène racémique, le 10-hydroxy-nor-kétotifène racémique et des isomères optiquement actifs de kétotifène, norkétotifène, 10-hydroxy-kétotifène et 10-hydroxy-norkétotifène, possédant des effets antiallergiques et anti-inflammatoires mais étant dépourvus des effets secondaires sédatifs importants limitant les doses du kétotifène.

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