Optically active pyrrolidinedione and pyrrolidinone derivatives

Details Optically active pyrrolidinedione and pyrrolidinone derivatives Optically active pyrrolidinedione and pyrrolidinone derivatives

C - Chemistry, Metallurgy

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C07D 207/273 (2006.01) C07C 227/32 (2006.01) C07D 207/263 (2006.01) C07D 207/38 (2006.01) C07D 207/404 (2006.01) C07D 209/20 (2006.01) C07D 319/06 (2006.01) C07D 403/06 (2006.01)

Patent

CA 1283921

ABSTRACT OF THE DISCLOSURE Optically-pure pyrrolidinedione and pyrrolidinone derivatives are described, which are obtained as synthetic intermediates in a process for the production of optically-pure 4-amino-3-hydroxycarboxylic acid derivatives, useful for the preparation of peptides that inhibit renin. The intermediates have the formula: Image wherein W' is an N-protecting group, R"1 is a variety of hydrocarbon radicals, Q is a hydroxyl group, and Q' is non-existent (in which case the broken line is an additional bond) or a hydrogen atom. Q and Q' taken together may represent an oxygen atom.

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