G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/58 (2006.01) A61K 9/51 (2006.01) A61K 49/04 (2006.01) G01N 21/35 (2006.01)
Patent
CA 2619676
The present invention refers to nanoparticles having optically fluorescent activity. In more detail, the invention refers to a nanoparticle matrix comprising a co- aggregate of at least one charged polyelectrolyte and at least one oppositely charged active agent, wherein the active agent is a hydrophilic optically fluorescent agent, and the invention further refers to a nanoparticle comprising said nanoparticle matrix. Optionally, the nanoparticle is surface modified. The invention also refers to a method for preparing said nanoparticle, and to a method of surface modification. Furthermore, the invention refers to uses of said nanoparticlein vitro and in vivo, and to methods for in vitro and in vivo diagnosis.
La présente invention concerne des nanoparticules ayant une activité optiquement fluorescente. De manière plus détaillée, l'invention concerne une matrice de nanoparticules comprenant un co-agrégat d~au moins un polyélectrolyte chargé et d~au moins un agent actif chargé de manière opposée, l'agent actif étant un agent hydrophile optiquement fluorescent, et l'invention concerne en outre une nanoparticule comprenant ladite matrice de nanoparticules. Éventuellement, la nanoparticule est modifiée en surface. L'invention concerne également un procédé de préparation de ladite nanoparticule et un procédé de modification de la surface. En outre, l'invention concerne des utilisations de ladite nanoparticule in vitro et in vivo, et des procédés de diagnostique in vitro et in vivo.
Fischer Katrin Claudia
General Sascha
Licha Kai
Bayer Schering Pharma Ag
Marks & Clerk
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