C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/62 (2006.01) A61K 31/365 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) C07D 339/08 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2184068
The present invention relates to a method for synthesis of optically pure stereogenically 4-aryl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, and additionally as inhibitors of cyclooxygenase and 5-lipoxygenase. The invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis, and in the treatment of various inflammatory pathologies, especially arthritis.
L'invention concerne un procédé de synthèse d'acides 4-aryle-2-hydroxytétronique optiquement purs stéréogéniquement labiles à partir d'aldéhyde optiquement pur. L'invention concerne également l'utilisation desdits composés optiquement purs en tant qu'inhibiteurs puissants de l'aggrégation plaquettaire par un travail au niveau de la cyclooxygènase, et de plus en tant qu'inhibiteurs de cyclooxygènase et de 5-lipooxygènase. L'invention concerne en outre l'utilisation pharmaceutique desdits composés dans le traitement de maladies des artères coronaires, notamment dans le traitement et/ou la prévention de l'athérosclérose, et dans le traitement de diverses pathologies inflammatoires, notamment de l'arthrite.
Hopper Allen T.
Witiak Donald T.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ohio State University Research Foundation
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