C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01) A61K 31/47 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 313/00 (2006.01)
Patent
CA 2364705
The invention concerns in particular compounds of general formula (a) wherein: R¿1? represents a lower alkyl radical; R¿2?, R¿3?, R¿4? and R¿5? independently represent H, a halo radical or OSO¿2?R¿10?; R¿6?, R¿7?, R¿8?, R¿9? and R¿10? represent different variable groups. Said topoisomerase-inhibiting compounds are particularly useful as anticancer medicines.
L'invention concerne notamment les composés de formule générale (a), dans laquelle R1 représente un radical alkyle inférieur; R2, R3, R4 et R5 représentent, indépendamment, H, un radical halo ou -OSO2R10; R6, R7, R8, R9 et R10 représentent divers groupes variables. Ces composés, inhibiteurs de topoisomérases, sont particulièrement intéressants en tant que médicaments anti-cancéreux.
Bigg Dennis
Lanco Christophe
Lavergne Olivier
Rolland Alain
Goudreau Gage Dubuc
Ipsen Pharma S.a.s
Societe de Conseils de Recherches Et D'applications Scientifique
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