Optically pure (-) norcisapride for treating digestive tract...

Details Optically pure (-) norcisapride for treating digestive tract... Optically pure (-) norcisapride for treating digestive tract...

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/44 (2006.01) A61K 31/4468 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2224005

Methods are disclosed utilizing the optically pure (-) isomer of norcisapride. This compound is a potent drug for the treatment of gastro-esophageal reflux disease, emesis, dispepsia and other conditions while substantially reducing the concomitant liability of adverse effects associated with cisapride. The (- ) isomer of norcisapride also avoids the adverse drug interactions associated with racemic cisapride and other therapeutic agents.

L'invention porte sur un procédé d'utilisation de l'isomère (-) optiquement pur de norcisapride. Ce composé est un médicament puissant destiné au traitement des reflux gastro-oesophagiens, des vomissements, de la dyspepsie et autres états similaires tout en réduisant notablement les effets indésirables concomitants associés au cisapride. L'isomère (-) optiquement pur de norcisapride empêche également les interactions médicamenteuses indésirables associées au cisapride racémique et à d'autres agents thérapeutiques.

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