A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 2/16 (2006.01) A61L 2/00 (2006.01) C07K 1/14 (2006.01) C07K 16/06 (2006.01) C07K 16/18 (2006.01) C07K 16/34 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2527138
The solvent-detergent (S/D) process is used to inactivate enveloped viruses in plasma products. While concentrations of 1.0% detergent and 0.3% tri-n-butyl phosphate solvent have been considered necessary for robust removal of viral activity, we show the effectiveness of solvent-detergent treatment after fractionation and nanofiltration of an immune gamma globulin preparation, which required significantly reduced concentrations of solvent and detergent. Reduced levels of solvent and detergent lead to greater efficiencies in their removal post-inactivation with the potential for greater yields and decreased processing costs.
Autenrieth Stephen M.
Van Holten Robert W.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Clinical Diagnostics Inc.
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