Optimised formulation of tobramycin for aerosolization

Details Optimised formulation of tobramycin for aerosolization Optimised formulation of tobramycin for aerosolization

A - Human Necessities

61

K

A61K 9/72 (2006.01) A61K 31/7036 (2006.01)

Patent

CA 2452638

The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room temperature. Said formulation can be advantageously used for the treatment and prophylaxis of acute and chronic endobronchial infections, in particular those caused by the bacterium Pseudomonas aeruginosa associated to lung diseases such as cystic fibrosis.

L'invention concerne une préparation à base de tobramycine destinée à être administrée en aérosol, sous forme de solution isotonique sans additifs dont le pH a été optimisé pour assurer une durée de conservation adéquate à température ambiante. Cette préparation peut être utilisée avantageusement pour le traitement et la prévention d'infections endobronchiques aiguës et chroniques, en particulier celles provoquées par la bactérie <i>Pseudomonas aeruginosa</i> associée aux maladies pulmonaires, telles que la mucoviscidose.

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