Optimization of binding proteins

Details Optimization of binding proteins Optimization of binding proteins

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07H 21/00 (2006.01) C07K 16/00 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2098824

2098824 9211272 PCTABS00014 The invention relates to methods for manipulating nucleic acids so as to optimize the binding characteristics of an encoded binding protein by providing two or more nucleic acids encoding binding proteins having at least one set of splicing sites, the set of splicing sites flanking opposite ends of one or more encoded binding domains; mixing the nucleic acids to produce a parent population of mixed nucleic acids encoding binding proteins; and randomly incorporating the binding domains between the nucleic acids through the set of splicing sites to produce a different population of nucleic acids encoding binding proteins wherein at least one binding protein is characterized by substantially different binding characteristics than a member of the parent population.

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