Optimization of transgene expression in mammalian cells

Details Optimization of transgene expression in mammalian cells Optimization of transgene expression in mammalian cells

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 48/00 (2006.01) C07K 14/02 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2483050

The present invention relates to vectors, compositions and methods for delivering transgenes into mammalian cells. The invention also relates to genetic constructs and recombinant cells suitable to produce such transgenes. The invention more particularly relates to a vector suitable for transgene delivery into mammalian cells, wherein said vector comprises a chimeric genetic construct comprising a transgene operably linked to at least two distinct posttranscriptional regulatory elements functional in mammalian cells. This invention can be used in experimental, research, therapeutic, prophylactic or diagnostic areas.

La présente invention concerne des vecteurs, des compositions et des méthodes permettant d'administrer des transgènes dans des cellules mammifères. L'invention concerne également des constructions génétiques et des cellules recombinées permettant de produire ces transgènes. Plus particulièrement, l'invention concerne un vecteur permettant d'administrer des transgènes dans des cellules mammifères, ledit vecteur comprenant une construction génétique chimérique renfermant un transgène lié fonctionnel à au moins deux éléments régulateurs post-transcriptionnels distincts, ces éléments étant fonctionnels dans des cellules mammifères. L'invention peut être utilisée à des fins d'expérimentation, de recherche, de traitement, de prévention ou de diagnostic.

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