Optimized antibodies that target cd19

Details Optimized antibodies that target cd19 Optimized antibodies that target cd19

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C12N 15/13 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2658557

Antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody, and methods of using the antibodies.

La présente invention décrit des anticorps qui ciblent CD19. Les anticorps comprennent au moins une modification par rapport à un anticorps parent, laquelle modifie l'affinité à FcggR ou modifie une fonction d'effecteur par rapport à l'anticorps parent. L'invention concerne également des procédés d'utilisation de tels anticorps.

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