Optimized cd40 antibodies and methods of using the same

Details Optimized cd40 antibodies and methods of using the same Optimized cd40 antibodies and methods of using the same

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2669412

The present invention describes antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

La présente invention concerne des anticorps qui ciblent CD40, lesdits anticorps comprenant au moins une modification par rapport à un anticorps parent, ladite modification modifiant l'affinité envers un FcyR ou modifiant la fonction de l'effecteur en comparaison de l'anticorps parent. L'invention concerne également des procédés d'utilisation des anticorps selon l'invention.

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