C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 47/48 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01)
Patent
CA 2692693
Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
La présente invention concerne une séquence d'ADN optimisée codant le fragment d'anticorps scFv(FRP5). Cette nouvelle séquence empêche la génération de sous-produits non souhaités dans le contexte d'une protéine de fusion scFv(FRP5)-ETA et de protéines de fusion contenant scFv(FRP5) exprimées de manière bactérienne. La séquence d'ADN du domaine scFv(FRP5) de scFv(FRP5)-ETA a été modifiée en échangeant un codon distinct, empêchant ainsi le commencement interne sinon possible de la traduction des protéines.
Dalken Benjamin
Schwarz Sylvia E.
Wels Winfried S.
Goudreau Gage Dubuc
Topotarget Germany Ag
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