Optimized dosing with anti-cd4 antibodies for tolerance...

Details Optimized dosing with anti-cd4 antibodies for tolerance... Optimized dosing with anti-cd4 antibodies for tolerance...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2570849

The present invention is based, at least in part, on the finding that tolerance can be induced by inhibition of CD4+ cells (and optionally CD8+ cells). Accordingly, the optimized dosing methods of the invention are useful in treating a primate, e.g., a human, by inhibiting CD4+ T cells to induce tolerance to at least one antigen, e.g., self or foreign, such as for inducting tolerance in a primate against a soluble or a cell bound antigen (e.g., an allogeneic or xenogeneic transplanted antigen).

L'invention se base au moins en partie sur une découverte selon laquelle on peut induire une tolérance par inhibition de cellules CD4+ (et éventuellement de cellules CD8+). En conséquence, les procédés de dosage optimisé de l'invention s'avèrent utiles pour traiter des primates (dont l'homme) par inhibition de cellules CD4+, pour induire chez le primate une tolérance à au moins un antigène (auto ou exo) soluble ou lié à une cellule (par exemple un antigène allogène ou xénogène transplanté).

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