A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) C07K 14/025 (2006.01) C12N 15/37 (2006.01) C12N 15/81 (2006.01)
Patent
CA 2539168
Synthetic DNA molecules encoding the HPV45 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV45 L1 protein, wherein said polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV45 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV45 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
L'invention concerne des molécules d'ADN codant la protéine HPV45 L1 et spécifiquement des polynucléotides codant cette protéine HPV45 L1, lesdits polynucléotides ayant été optimisés pour l'expression de haut niveau dans une cellule de levure. Les molécules synthétiques peuvent être utilisées pour produire des particules HPV45 de type virus (VLP), ainsi que des vaccins et des compositions pharmaceutiques renfermant ces particules HPV45. Les vaccins selon l'invention assurent une immunoprophylaxie contre l'infection au papillomavirus par anticorps de neutralisation et immunité à médiation cellulaire.
Brownlow Michelle K.
Bryan Janine T.
Jansen Kathrin U.
Schultz Loren D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
LandOfFree
Optimized expression of hpv 45 l1 in yeast does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Optimized expression of hpv 45 l1 in yeast, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optimized expression of hpv 45 l1 in yeast will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1910301